Molecular and cellular mechanisms of aging are the main contributors to age-related decline, frailty, diseases and multimorbidity. The contributions of these aging mechanisms vary between different types of organisms, cell types and tissues, but they are conserved over large evolutionary distances and genetic, lifestyle and pharmacological interventions can ameliorate their effects. These findings have led to the geroscience approach, which aims to develop broad-spectrum preventative defences against age-related impairments, by targeting their main risk factor, aging. Important current challenges in the field are (1) to assess the roles of somatic mutation and impaired genes expression, (2) to understand the origins of the highly damaging age-related increase in inflammation, (3) to specify the multiple interactions between organs that combine to produce age-related impairments, (4) to better understand interactions within cells that lead to decline in their function, (5) to evaluate the promise and challenges of regenerative interventions and cellular reprogramming.  

This fifth meeting will explore these topics, with particular emphasis on new knowledge and its potential for translation into benefits to human health during aging.

Confirmed Plenary Speakers

Anne Brunet (Stanford University)
Vishwa Deep Dixit (Yale School of Medicine)

Confirmed Invited Speakers

Andrea Ablasser (EPFL)
Roz Anderson (University of Wisconsin-Madison)
Constanza Cortes (University of Southern California)
Andrew Dillin (University of California, Berkeley)
Oliver Hahn (Calico Labs)
Adam Hughes (University of Utah)
Leanne Jones (University of California, San Francisco)
Jason Karpac (Texas A&M University)
Jacob Kimmel (NewLimit)
Heidi McBride (McGill University)
Emmanuelle Passegué (Columbia University)
Lena Pernas (University of California, Los Angeles)
Luca Scorrano (University of Padua)
Saul Villeda (University of California, San Francisco)
David Walker (University of California, Los Angeles)
Ashley Webb (Buck Institute for Research on Aging)
Matthew Yousefzadeh (Columbia University)

Key Sessions

•    Somatic mutation 
•    Origins of age-related inflammation
•    Metabolism and physiology
•    Inter-organ communication
•    Inter-organelle communication
•    Cellular reprogramming

Target Audience

Scientists at all career stages and working in contexts across academia and industry who are doing or may in the future do work to understand the aging process and ways in which its effects on health at later ages can be ameliorated.

Education Need

The meeting will present and discuss cutting edge work on several mechanisms of aging and the promise and challenges of translating them into interventions to improve human health during aging.

Although the programme has not yet been released, we are able to confirm that the conference should begin no earlier than 14:00 with opening comments on Saturday 04 October 2025. The conference will conclude no later than 12:30 on Tuesday 07 October 2025.