Due to high hotel occupancy levels, we have closed the registration deadline as hotel availability is changing daily. Please contact Rosie to check if any spaces remain available. If you have already registered for the conference, you can no longer extend your stay via your Fusion account. Again, please contact Rosie to check if we can accommodate your extra nights and/or accompanying guests.

Mitochondria act at the interface of numerous processes critical for cellular function and organismal health. Long recognized as the powerhouses of the cell, mitochondria are emerging as hubs for cellular metabolism, redox balance, signalling, gene expression, detoxification, and ion homeostasis. Mitochondrial maintenance is critical for proper development and function of cells and tissues, and mitochondrial dysfunction underlies numerous disease processes ranging from severe childhood mitochondrial disorders, to heart disease, neurodegenerative disorders, cancer, and aging itself. This conference will bring together scientists and clinicians with expertise in a breadth of mitochondrial biology to explore topics at the interface of basic and translational biology. Mitochondrial basic mechanisms of organelle regulation, mitochondrial mechanisms of disease, cutting edge technologies, and interventional strategies will be emphasized in interactive scientific sessions.

Confimed Invited Speakers

Kivanc Birsoy (Rockefeller University)
UNDERSTANDING THE ROLE OF ORGANELLAR REDOX HOMEOSTASIS IN PHYSIOLOGY AND CANCER
Navdeep S. Chandel (Northwestern Medicine)
MITOCHONDRIA AS SIGNALING ORGANELLES
Edward Chouchani (Harvard University / Dana-Farber Cancer Institute)
David Finlay (Trinity College Dublin)
FUELLING NATURAL KILLER CELL METABOLISM IN DIFFERENT TISSUE NICHES
Susan Kaech (Salk Institute)
Naama Kanarek (Harvard Medical School)
METABOLIC VULNERABILITY OF LEUKEMIA IN THE BRAIN
Pekka Katajisto (University of Helsinki)
Samantha Lewis (University of California, Berkeley)
THE MITOCHONDRIAL CENTRAL DOGMA IN HOMEOSTASIS AND STRESS
Luke O'Neill (Trinity College Dublin)
ADVENTURES WITH ITACONATE, THE MITOCHONDRIAL METABOLITE THAT KEEPS ON GIVING
Natasha Pavlova (University of Utah)
POLYGLUTAMINE TRACTS AS SENSORS OF GLUTAMINE AVAILABILITY
David Pagliarini (Washington University in St. Louis)
SYSTEMS BIOCHEMISTRY APPROACHES FOR DEFINING MITOCHONDRIAL PROTEIN FUNCTIONS
Erika Pearce (John Hopkins University)
DELINEATING THE METABOLIC SIGNALS THAT REGULATE IMMUNE CELL DIFFERENTIATION AND FUNCTION
Josh Rabinowitz (Princeton University)
Jared Rutter (University of Utah)
METABOLISM, CELLULAR DECISIONS AND THE LANGUAGE THAT UNITES THEM
Dylan Ryan (University of Cambridge)
MITOCHONDRIAL CONTROL OF INFLAMMATORY MACROPHAGE FUNCTION
Luca Scorrano (University of Padua)
Shabnam Shalapour (The University of Texas MD Anderson Cancer Center)
DIETARY MACRONUTRIENT COMPOSITION DRIVES DIFFERENTIAL “IMMUNO-METABOLIC” RESPONSES DICTATING THE MECHANISM OF MALIGNANT TRANSFORMATION
Gerald Shadel (Salk Institute)
MITOCHONDRIAL NUCLEIC ACID-MEDIATED INNATE IMMUNE SIGNALING
Celeste Simon (University of Pennsylvania)
THE UREA CYCLE IN HEALTH AND DISEASE
Jessica Spinelli (UMass Chan Medical School)

Target Audience

• Basic scientists studying mechanisms of mitochondrial and cell biology
• Clinicians and translational biologists interested in mitochondrial disease
• Immunologists studying mitochondrial function and the role of mitochondria in immune health and disease
• Scientists studying processes where mitochondria are important (metabolism, aging, cancer, heart function, etc.)

Educational Need

Mitochondria function at the intersection of many important areas of biology and biomedicine, but there are limited opportunities for people studying different areas of biology where mitochondria are important (aging, neurodegenerative disease, inherited disorders, mitochondria disease, heart disease, myopathies and muscular dystrophies, evolutionary biology, obesity, diabetes, kidney disease, etc.) to come together at one meeting. The primary outcome we hope to stimulate is interaction and cross fertilization of ideas between these diverse scientists leading to new collaborations and synergistic advances.