Transposable elements (TEs), which constitute nearly half of the human genome, were once deemed ‘junk DNA’. However, recent technological advancements have led to a resurgence of research interest into their functional impact and molecular mechanism, particularly focusing on the major Type I TEs (also known as Endogenous Retrotransposable Elements or EREs). These elements, integrated into the human genome over millions of years, have undergone evolutionary changes that now make them influential factors in human biology. EREs represent a rich yet understudied source of regulatory sequences that drive the evolution of human genomes and epigenomic landscape. ERE dysregulation has been widely reported in human diseases including cancer, neurodegenerative diseases, and aging. 

The primary goal of this meeting will be to facilitate the exchange of ideas among academic scientists and clinical researchers from diverse backgrounds. This Fusion meeting will boost unconventional interactions and foster innovative, cross-disciplinary ideas and collaborations that could transform existing paradigms.

To accelerate progress in both basic and translational research in this cutting-edge field, this meeting will not only review previous discoveries but also communicate ongoing and unpublished work, and hopefully inspire new modes to translate basic discoveries from bench to the bedside.

Key Sessions

The session themes will cover ERE in various contexts:

• Evolution
• Development
• Pathology
• Epigenetic Regulation
• Immunology
• Gene Regulatory Network
• New Therapeutic Strategies

We will also organize discussion panels for novel technologies of ERE research and targeting EREs for therapy, such as AI-based approaches and RNA therapy.

Target Audience

This conference is targeted to basic research scientists and translational researchers who is active in ERE related field and who wants to find collaborative opportunities. We hope to welcome scientists from all stages including early-career trainees.

Educational Need

This conference will open the new horizon of ERE research and spark novel ideas for how to translate basic discoveries from bench to the bedside. The audience will learn the forefront of ERE’s latest discoveries and new technological progress.
 

Programme timings to be confirmed shortly.